I also experience this, but with oxycontin, the long-acting form of percocet with no tylenol. They did get better after a while, but it makes sense that we have headaches, as they say that when you take an over the counter med regularly, like the tylenol in some pain drugs, you can get rebound headaches. I take percocet because I have sever arthritis and only at the most take 3 a day. I do wake up in the mornings sometimes around 2 or 3am to go to the bathroom and then I go back to sleep. How to use Percocet. See also Warning section. Read the Medication Guide provided by your pharmacist before you start taking oxycodone/acetaminophen and each time you get a refill. You can try whatever works best for you I just stay away from tylonol because of the possable liver damage,plus with me ibuprofen just works better & I can take more without worrying. Percocet have tylonol percodan have aspirin if that helps with your decision. Hope this helps & good luck. A headache while taking oxycodone. you must not being taking enough LOL. You can take tylenol or ibuprofen if you really need something. You can take tylenol or ibuprofen if you really need something. I've had some really bad headaches while taking PERCOCET for severe back pain. Is this a side effect? Has anyone else had this happen? It helps with the back pain but the headaches make it almost not worth it! Is there something that I can take for the headache on top of taking the Percocets? Common Questions and Answers about Percocet withdrawal headache percocet I would think that this being the third day back on the Percocet that any withdrawal symptoms would have disappeared by now. Percocet (oxycodone and acetaminophen) is a combination drug consisting of an opioid and a pain reliever and fever reducer (analgesic and antipyretic) used for the management of moderate to severe pain, usually for an extended time period.